A case of E. coli meningitis treated with systemic and intrathecal ampicillin.

THE following case is of interest in that it illustrates the effectiveness of a new penicillin derivative, ampicillin ('Penbritin') (6 D (-) o-amino-phenylacetimido penicillanic acid) which is active against a number of Gram-negative as well as Grampositive organisms. Preliminary reports on Penbritin appeared in the British Medical Journal on July 22, I96I (Rolinson and Stevens, Brown and Acred, Knudsen, Rolinson and Stevens, Stewart, Coles, Nixon and Holt).